I agree with the others here - once you're familiar with the strikes, you don't need to shoot everything in between the major areas, only those in the darkness zones. Those zones are generally the most important areas (though there is an occasional outdoor enemy that needs defeating), but the rest are mostly the common patrol areas
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There are those who shove past all the enemies in the darkness zones to try to get to the boss with little delay.
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But don't you need to clear all the enemies in darkness zones to progress? I can't remember off-hand
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No, the darkness zones just tell when the enemies are leveled and harder, devils lair has two passable groups after the darkness zone, archon priest is a big passable area until you hit a wave wall.