Not because it's from the same franchise that brought us Colonial Marines, but defenceless horror games aren't my style.
I love Condemned. But I can defend myself. I picked up Outlast on PS4 and have barely played it because I get so -blam!-ing terrified it gives me a headache. :( Will Isolation have the same effect on me? Hope not. :/
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You can fight back in Isolation. There are guns, and I think a flamethrower. Chances are you can only injur and almost kill the alien, but never actually defeat it until the end.