True Ghost - You don't disturb anyone and you don't kill or knockout anyone.
Ghost - You only knockout people and use non lethals while not being detected.
Panther - You stay in the shadows and use lethals while not being detected
Assault - You run and gun while always being detected.
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I played Ghost until I realized it was both harder and you get more points for just sneaking past people. So I started doing True Ghost halfway through the Blacklist campaign. I had a blast, though there were a couple missions I got detected where there's no way in hell I ever actually got detected so I'm kinda peeved about that.