I've tried 2 different asus strix 1070tis. My one card worded just fine. Then all of a sudden the last 2 weeks or so broccoli within 30sec-3min of loading into anywhere. I've reinstalled drivers. Used programs to wipe the drivers and data from drivers then downloaded my specific drivers through nivida not GeForce experience. I've had 1 card in my system. I've had both. Used 2 different sli bridges. I've changed game ssds(corsair mp600&samsung 970evo nvme) . Reinstalled the game itself 3 times. I've tried every window/full screen mode. I have a pc just to play d2 and now I can't even do that and I'm going to miss out on my conquer title this season because of it.(side note I understand sli is basically dead. Just saying I've ruled out a bad bridge. And I do run d2 in single gpu mode.) I've tried everything I can.
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Try disabling nvidia shader cache