This is mostly a theory, but I think Ikora will die next in the Savathun DLC similar to how Cayde-6 died in the Forsaken DLC. This idea came to mind when I realized how much stress the tower is facing. Currently we are dealing with the Cabal and soon have to deal with the Hive Queen and her army while the darkness clings close near us. When Ikora die's, Zavala will be in even more distress. For the last DLC/end of Destiny 2, Zavala may live or die. In short, "Gaurdian down..."
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"Killer in plain sight" (Season of Arrivals) "Clever looking woman" (Forsaken lore describing Savathun's appearance in person) I suspect Ikora Rey is revealed to be the Witch Queen all along and that the real Ikora Rey has been long dead since the Red War. She probably never made it out of the City when Ghaul attacked.