Occasionally I will hit targets pretty darn head on in Crucible and they take anyway from 60 to 90 damage. It isn't happening every time, but just often enough that it is very frustrating.
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I remember needing 1 sword kill to do a bunker bounty and I died, using almost all my ammo on 1 person who backpetals into no-hit-detection safety. I swiped them first from behind, ran off because I thought it landed... yeah no.