So ok, They have to tank the blast, right? So if we're going Tenno, Wukong, who can gain immortality with Defy, so he can't die, or Inaros, he'd be massively injured, but he'd just enter his sarcophagus, and self Rez if anyone is nearby. Come to think of it, any Tenno could survive, as revives are canon. You have to kill the operator which is in a ship cloaked in a alternate dimension.