Mini nuke, or a rocket (gjallarhorn)
Hmmmm.... Real tough decision
[spoiler]mini nuke FTW[/spoiler]
English
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Or RYNO, the most OP gun of all time. It's essentially an even more powerful Fat Man that rapid fires.
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Also scarab gun beats all
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It does but it's not classified as a Rocket Launcher. But it definitely obliterates everything.