Who would win?
I'm putting all my money on Goku.
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Well... I think it would go something like this. All the guardians would be dropping heavy damage onto Goku. Goku would be standing there charging a very powerful attack, likely yelling. No damage is registering and Goku is still yelling. The guardians would think they're lagging. Three days later Goku would unleash his attack and end the Destiny universe