I think it was before the Human-Forerunner War. Forthencho destroyed Forerunner planets that were beginning to show signs of infection, which initiated the War.
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Edited by Mechetti: 11/22/2014 5:53:45 AMAlas, the forerunners must have known, as the forerunners had it unleashed upon them before.
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From what I'd read, when Humans tested the Powder, they found nothing that suggested it would have any negative consequences long term.
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As the precursors designed it.
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Yep, as it was meant to be revenge against the forerunners, I doubt they knew of the source, either. Of course, LoA could probably blow everything I'm saying out of the water right now.
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Same. The Archive guys knowledge put any of ours to complete shame.