Ah yes, the Hand Cannons. The experience of seeing your rounds pierce the cranium of your alien oppressors that only they can provide. Whose wielders tower over the filthy Scout, Pulse, and Auto Rifle plebians.
Come, my brethren, gather in this place and share your knowledge, tales, and advice to your fellow Marksmen.
I offer my own small piece of input: Acquiring Chain of Woe (exclusive to the mighty Hunter Mustard Rice (a topic for another day)), armor which increases Hand Cannon reload times, and a Hand Cannon itself that sports a 'melee hits reduce the reload time of this weapon' upgrade will result in all whom you come across fleeing back to the Darkness from whence they came.
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Using the devil you know... Fully upgraded, in combination with the invisible hand m7 (fire shotgun) and the Gjallarhorn (exotic launcher) so far it's proven to be an effective and extremely deadly combo. On Warlock by the way.