Sherry Birkin and Jake Muller are my definite favorite. They're perfect together and at the end of RE6 they become so much closer and it's just really awesome :D
Elizabeth and Booker are a strong second.
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Edited by cxkxr: 9/26/2013 1:54:40 AMSpyro the Dragon and his Dragonfly or Crash Bandicoot and Aku Aku!