*WARNING* Spoilers abound in this place!!!!!
Below is a spoiler for The Last of Us.
[spoiler]
[url]http://www.youtube.com/watch?feature=player_detailpage&v=OBJLBYdDwVw#t=599s[/url]
For me, it is in The Last of Us when Sam and Henry die. I have only has a short amount of time with them, but the striking tug that I got from the fact that they are brothers, sent me into tears.[/spoiler]
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Yep, probably the opening of The Last of Us for me, it was so sad. Though the whole game is anyways lol