World of Warcraft. DC universe online. Really just about any MMO type game that has PvE and PvP.
Now don't misunderstand. When I say separate most don't actually lock them off from each other like I mentioned in my post. They do however have weapons/armor built for PvE and separate weapons/armor for pvp. You can take your PvE set into PvP, sure, but there would be no point because it'll be completely ineffective.
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So, just like Destiny already works?