You see thats different, Destiny is a loot based game, GOW is not and Halo Reach had a great hoard mode but it was not loot based. It's proven that Bungie can do it but when the game is based around loot and rewards, it makes it a bit difficult, and Destiny was repetitive to begin with. Most people will get bored by wave three.
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it would be possible if only the boss drops engrams and the you get 1 or 2 blues each round (a bit like strikes i guess) it would be repetitive but that would fix the loot problem of the equation