Your choice can be for various reasons: •Favorite overall game happens there. •Design. •Backstory. •Location of the Anime. •Pokémon introduced there. I would love to hear which region you choose and your more specific reason on why you favor it over the others. [spoiler]I'm caught between Hoenn and Sinnoh. Hoenn is very water focused. Sinnoh is more focused on the mountain. Both have great city and world design s. Unova and Kalos,I have no personal experience with. Kanto and Johto,You can't mess with the classics but not as good as Hoenn and Sinnoh to me.[/spoiler]