At least the lives of gen 3 synths. They have a free will, consciousness and emotions just like humans.
But on the other hand. They can be a serious threat to humanity. They are artificial. They are not created by nature. They have no soul. Or have they?
I always find myself on the fence.
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Well seeing as how me and the minute men gave the institute a lethal dose of freedom made proudly in the USA I'd say no synth lives don't matter Except paladin danse and nick Valentine