You can't compare a video game to a kid's show because a video game is generally balanced in some way for gameplay and they don't use the same foundational logic for power. A story for kids doesn't need to make sense or use any form of logic, so it can be as ridiculously over the top as it wants to be as long as it entertains the kids. However, let me list s couple ways that Goku would lose anyway, because these game mechanics don't need to be balanced for good gameplay. Oracles decide Goku doesn't exist. Vex win. Gorgons decide Goku doesn't exist. Vex win. Oryx takes Goku. Oryx wins.

Even then I don't think it'd be that simple because, like I said, Goku is a literal God now. By that logic the Oracles/Gorgons should've been able to just decide Oryx didn't exist. I also doubt Oryx could take Goku. Oryx taking things is comparable to Babadi's majin magic in the Buu saga.

It doesn't matter whether or not he's a god, he has no light. You can't pick and choose which pieces of lore matter when comparing two things that can't be compared fairly and logically. You have to use each set of lore in its entirety or use none at all. The oracles and Gorgons are the most powerful entities in the entire universe, but only inside the vault of glass. If Goku goes into the vault, he is subject to their will, regardless of how much of a children's story protagonist he is.

Goku could just destroy the whole planet of Venus with a Kamehameha Wave from space tho, thus negating even having to enter the vault.