Not really. Not in the sense of "frying your brain" it's more like you lose your grip on reality. You question what morality really is, it's a hell of an experience. But after taking it multiple times and still making a 32 on my ACT, I can all but promise it's safe for people with the proper mindset. In ample amounts, however, you will start hurting yourself. Not in a frying your brain way though. It's more of questioning every single thing down to the grass between your toes. That's why I stopped taking it, it will eventually alter your personality.