Yes but if you damaged him at the rate he regenerates he wouldn't die but would be un able to fight so he'd be out of the fight.
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That would require something with infinite amount of energy since what your doing requires and infinite amount of time. Also adds to the fact that if you obliterate him, you just -blam!-ed up and he's coming back in one piece. Now here's the problem: there is no such thing as unlimited energy.
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You could throw him into a star, lock him underwater, thrown in a volcano, etc.
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I'm with dead pool winning you don't have to nerd all over me :)