Iceman can freeze his ass solid and then store him in a deep freezer in his garage. I can give you dozens of these. You do not have to kill him to beat him. Leech can suppress his powers and Deadpools cancer would eat him alive at which point you can put him in a block of concrete and deposit him in the ocean. Spiderman and incapacitate him quite easily and put him in a block of concrete and deposit him in the ocean. Hulk smash an so on and so on ...

But all of those examples you gave are based on those characters getting the upper hand over deadpool? Because he's going to stand there and be frozen or hulk smashed? He's an expert of all forms of combat for a reason...

Iceman can freeze him easy and does not have to be close. He can freeze the moisture in the air if he wants to. Leech would need to be close which shouldn't be a problem unless Deadpool knew he was there. (I'll give you this one) Deadpool is not faster or stronger than Spiderman by any stretch of the imagination. This one is not even debatable. Spiderman wins every time and twice on Sunday. Hulk can bring a building down on him or crack the ground he is standing on. Hulk can also take getting cut with the blades in order to get close. Hulks massive strength gives him more than enough speed to close the gap.Not to mention ground smash and thunder clap for those ranged attacks. Sounds to me that you are of a singular mind that Deadpool is the be all end all and no amount of common (comic) sense will dissuade you from your fanboy love of Deadpool.