Prove me wrong. I'm a lore expert on Destiny, so odds are I can refute any argument you provide that favors Destiny. Vegeta and Goku would beat the entire Destiny universe in a fight.
Lets also assume they know the mechanics for the VoG and Crota's End.
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Goku and Vegeta. Even if Guardians' supers are somehow powerful enough to kill them, they won't be able to land them due to how fast Goku and Vegeta are. Hell, saiyans have been shown to stop bullets with zero effort, so even a Gunslinger's super wouldn't be quick enough