Prove me wrong. I'm a lore expert on Destiny, so odds are I can refute any argument you provide that favors Destiny. Vegeta and Goku would beat the entire Destiny universe in a fight.
Lets also assume they know the mechanics for the VoG and Crota's End.
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If they know the mechanics then there's no doubt in my mind that they can beat anyone in the Destiny universe. Hell, I think Vegeta could do it by himself.