I can play on either a 55" Panasonic plasma or a 42" Samsung LCD. Both from about the same distance (about 9'). I find it's a little easier to play on the 42". With the 42" there's less of the gameplay left out on the periphery. Try moving closer to the screen while playing and you'll see what I mean. With a larger screen, or being closer to it, you end up having to move your eyes more or even your head in order to see it all. Being a little farther back or on a smaller screen lets you see more if it with less eye/head motion.