A fusions weakest point is charging and it's got a very loud audio sound which while I can't really replicate the sound it starts kinda weak than gets a bit louder than the blast happens the best counter is to either A. wait till the sound stops or B. Go when you hear the loud shot sound since they have a pretty long delay long enough to allow primaries a chance to take them down. Another way is range combat since the two nerfs they got were a range and charge time nerf so if you play range it'll be tough for em not impossible however.
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It seems like so many folks are so good at pre-charging and they crush me at 20 meters. It feels impossible to have a real duel lol But, granted, I'm also the guy still getting wrecked by Witherhoards and flying toasters >_< lol
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Another way is fast movement keep in mind unlike a shotgun where every bullet comes out at once a fusion shoots it like a pulse meaning movement could mess it up might not be as strong as the other ways I mentioned but it should help