When you use witherhoard on Panoptes in the final fight for the curse of osiris campaign. Panoptes will continue to take damage from witherhoard even after the damage phase is over (When he's ment to be immune). If Panoptes dies your game will be soft locked (somewhat). Everything will happen like normal such as the enemies spawning, but when the part with Panoptes trying to remove you from the infinite forest, it won't happen as normal. Osiris will do his thing up to the damage phase but then you are left not being able to do anything. If will force you to die (Eye of Panoptes buff) and you will reset from last checkpoint the fight will then continue as normal when you reset. Clip above will show you what I mean.