originally posted in:Halo Archive
Considering that the flood initially came from beyond the edge of the galaxy (if memory serves) it seems likely that at the very least wherever they can from is probably an infested hell hole.
English
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They originated from the Large Magellanic Cloud. Curiously enough, it is not infested in the slightest, and any remaining traces of the Precursors there was destroyed when Omega Halo was fired at the LMC.